Genetically Modified Models

CRO Expertise

GENETICALLY MODIFIED ANIMALS
PROGRAM OVERVIEW (HOUSING / BREEDING)

Customizable rodent colony management
• Custom breeding strategies
• Inducible models
• Conditional models
• Timed pregnancies
• Shipments of colony animals nationally and internationally
CARD methods for rederivation, IVF, and strain rescue
Generation of customized transgenic and knockin mouse models
Phenotypic characterization
Procedural manipulations
Pharmacology
In vitro laboratories
• Standard PCR genotyping
• Real-time PCR genotyping

EXPERIENCE IN DIVERSE
ANIMAL MODELS (CLIENT OWNED)

Citrullinemia type I and hyperammonemic syndromes
Hemophilia B
Cystic fibrosis
Phenylketonuria
Polycystic kidney disease, juvenile
Ornithine transcarbamylase (OTC)
Wilson’s disease
Ectopic mineralization
Stargardt macular dystrophy (STGD)
Osteogenesis imperfecta (OI)
Glucose-6-phosphatase defi ciency (GSD1a)
Mucopolysaccharidosis type II (MPS II)
Fabry
Gaucher
ALS
HexB
Glycogen storage disease type II
Townes sickle mice
BKB2

Colony Housing Options

Maximum Exclusion

No murine pathogens or specified opportunists allowed

Our shower-in facility is free of all murine pathogens and specified opportunists. Space is available for mouse or rat colony housing in IVC housing. Strains may undergo quarantine procedures or onsite rederivation for introduction to this facility.

Specific Pathogen Free

No murine viruses allowed

For those colonies that do not meet the strict Maximum Exclusion health status and have specific permissible pathogens that are of no consequence to a client’s research needs. Space is available for mouse or rat colony housing in IVC or conventional rack systems.

Quarantine

Specific pathogens allowed

Breeding and support of animals with specific pathogens for crucial experiments can be done at Biomere’s quarantine facility while your model is cleaned up, saving you valuable time.