Ocular

CRO Expertise

Ocular Capabilities

Our global team of industry-leading scientists employ a variety of state-of-the-art techniques and imaging modalities to investigate the pharmacodynamics (PD), pharmacokinetics (PK) and safety of novel compounds targeted to treat ocular diseases.

Corneal neovascularization, choroidal neovascularization, cataract, glaucoma, and dry eye models are currently available from JOINN (China). Biomere (USA) has a variety of ocular models under development and has interest in collaborative model development on new and unique ocular models. Our combined preclinical and clinical research experience distinctively positions us to support our clients’ nonclinical ophthalmic needs.

ASSESSMENTSPECIESEQUIPMENT
Slit-lamp/anterior segmentMouse, rat, rabbit, NHPKowa handheld sli-lamp, Topcon slit-lamp, leica surgical scope
Indirect ophthalmoscope/fundusMouse, rat, rabbit, NHPKeeler indirect, Volk PictorPlus
Optical coherence tomography (OCT)Mouse, rat, rabbit, NHPHeidelberg Spectralis OCT +HRA
Electroretinogram (ERG)Rabbit, NHP*Diagnosys Espion
Intra ocular pressure (IOP)Rabbit, NHP*Tonovet
Gene expressionMouse and rat, (rabbit and NHP ex vivo)IVIS Spectrum
*Mouse and rat coming soon

Gene Therapy rat eye

COMPREHENSIVE DOSING TECHNIQUESSPECIES
Topical eyeMouse, rat, rabbit, NHP
Intravitreal injectionMouse, rat, rabbit, NHP
Subretinal injectionMouse, rat, rabbit, NHP
Subconjunctival injectionMouse, rat, rabbit, NHP
Intracameral injectionMouse, rat, rabbit, NHP
SuprachoroidalRabbit, NHP
Systemic delivery including oral,
subcutaneous, intraperitoneal, intrathecal,
intratracheal, and intravenous
Mouse, rat, rabbit, NHP
**Ocular models (such as corneal neovascularization, choroidal neovascularization, cataract, glaucoma, and dry eye) currently available with our partner, JOINN, in China. Biomere aims to bring some ocular models in-house by end of this year and is always open to collaboration on new or unique models.**

White Papers

Gene Therapies for Eye Diseases
Gene Therapies for Eye Diseases
Cell Therapies for Eye Diseases
Cell Therapies for Eye Diseases

Webinars

Molly Shoichet, University of Toronto – Regenerative Strategies in the Central Nervous System, Part One

Molly Shoichet, University of Toronto – Regenerative Strategies in the Central Nervous System, Part Two

Biomere Briefs

Subretinal Injection in a Sprague Dawley Rat

Subretinal Injection in a New Zealand White Rabbit

Subretinal Injection in a Rhesus Macaque

Technical Sheets

Ocular Overview

Posters

A Survey of Spontaneous Cataract in Senior Cynomolgus Monkeys with or without Diabetes

IOP-lowering Effect of Rhopressa® in Normotensive Rabbit, Dog and Monkey Eyes

Dry Eye in Ovariectomized Cynomolgus Monkeys – A 54 Months Follow-up Study