CRO Expertise

Ocular Capabilities

Our global team of industry-leading scientists employ a variety of state-of-the-art techniques and imaging modalities to investigate the pharmacodynamics (PD), pharmacokinetics (PK) and safety of novel compounds targeted to treat ocular diseases.

Corneal neovascularization, choroidal neovascularization, cataract, glaucoma, and dry eye models are currently available from JOINN (China). Biomere (USA) has a variety of ocular models under development and has interest in collaborative model development on new and unique ocular models. Our combined preclinical and clinical research experience distinctively positions us to support our clients’ nonclinical ophthalmic needs.

Topical eyeMouse, rat, rabbit, NHP
Intravitreal injectionMouse, rat, rabbit, NHP
Subretinal injectionMouse, rat, rabbit, NHP
Subconjunctival injectionMouse, rat, rabbit, NHP
Intracameral injectionMouse, rat, rabbit, NHP
SuprachoroidalRabbit, NHP
Systemic delivery including oral,
subcutaneous, intraperitoneal, intrathecal,
intratracheal, and intravenous
Mouse, rat, rabbit, NHP
**Ocular models (such as corneal neovascularization, choroidal neovascularization, cataract, glaucoma, and dry eye) currently available with our partner, JOINN, in China.





Corneal Wound Model

Rodent Sodium Iodate

Mouse Subretinal Injections

Rodent Laser CNV and Histology Slides

Gene Therapy rat eye

JOINN’s ophthalmology laboratory was established in 2012, in Suzhou. GLP compliant study services are championed by a scientific research team of 35+ professionals. This team is responsible for more than 500 service contracts assisting clients to complete 30 domestic and global IND submissions. Click here to view the JOINN Ocular Photo Gallery.

Slit-lamp/anterior segmentMouse, rat, rabbit, NHPKowa handheld sli-lamp, Topcon slit-lamp, leica surgical scope
Indirect ophthalmoscope/fundusMouse, rat, rabbit, NHPKeeler indirect, Volk PictorPlus
Optical coherence tomography (OCT)Mouse, rat, rabbit, NHPHeidelberg Spectralis OCT +HRA
Electroretinogram (ERG)Rabbit, NHP*Diagnosys Espion
Intra ocular pressure (IOP)Rabbit, NHP*Tonovet
Gene expressionMouse and rat, (rabbit and NHP ex vivo)IVIS Spectrum
*Mouse and rat coming soon

Click here to Connect to the International Liaison Team for more information regarding conducting studies JOINN/China.

Ocular Team

Natalie Brun, BS, RLATg
Small Animal
Study Director
Full Bio
Sarah Webb, BAS
Large Animal
Study Director
Full Bio
Eric Xie, MD, PhD
Director of Ophthalmology
JOINN Laboratories
Full Bio

White Papers

Gene Therapies for Eye Diseases
Visus – NHP Spontaneuos Cateracts ARVO 2023
Gene Therapies for Eye Diseases
Gene Therapies for Eye Diseases
Cell Therapies for Eye Diseases
Cell Therapies for Eye Diseases
BLOG POST: Opsin Expression in Retinal Ganglion Cells
BLOG POST: Levodopa Improves Vision in Neovascularized AMD
BLOG POST: Nanoparticles: New Strategies for Ocular Drug Delivery

All Biomere Blog Posts


Molly Shoichet, University of Toronto – Regenerative Strategies in the Central Nervous System, Part One

Molly Shoichet, University of Toronto – Regenerative Strategies in the Central Nervous System, Part Two

Technical Sheet

Ocular Capabilities

Biomere Briefs

Subretinal Injection in a Sprague Dawley Rat

Subretinal Injection in a New Zealand White Rabbit

Subretinal Injection in a Rhesus Macaque


A Survey of Spontaneous Cataract in Senior Cynomolgus Monkeys with or without Diabetes

IOP-lowering Effect of Rhopressa® in Normotensive Rabbit, Dog and Monkey Eyes

Dry Eye in Ovariectomized Cynomolgus Monkeys – A 54 Months Follow-up Study

A long-acting anti-VEGF biologic in development for durable wet AMD treatment

Peer-reviewed Publications

Intravitreal Administration of Stanniocalcin-1 Rescues Photoreceptor Degeneration with Reduced Oxidative Stress and Inflammation in a Porcine Model of Retinitis Pigmentosa

Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina

Data on SD-OCT image acquisition, ultra structural features, and horizontal tissue shrinkage in the porcine retina

Application Notes

Development of the Sodium Iodate Induced Model of Retinal Degeneration and AMD

Development of a Rabbit Corneal Injury Repair Model

JOINN Locations

Joinn Locations