CRO Expertise
Ocular Capabilities
Our global team of industry-leading scientists employ a variety of state-of-the-art techniques and imaging modalities to investigate the pharmacodynamics (PD), pharmacokinetics (PK) and safety of novel compounds targeted to treat ocular diseases.
Corneal neovascularization, choroidal neovascularization, cataract, glaucoma, and dry eye models are currently available from JOINN (China). Biomere (USA) has a variety of ocular models under development and has interest in collaborative model development on new and unique ocular models. Our combined preclinical and clinical research experience distinctively positions us to support our clients’ nonclinical ophthalmic needs.
| ASSESSMENT | SPECIES | EQUIPMENT |
|---|---|---|
| Slit-lamp/anterior segment | Mouse, rat, rabbit, NHP | Kowa handheld sli-lamp, Topcon slit-lamp, leica surgical scope |
| Indirect ophthalmoscope/fundus | Mouse, rat, rabbit, NHP | Keeler indirect, Volk PictorPlus |
| Optical coherence tomography (OCT) | Mouse, rat, rabbit, NHP | Heidelberg Spectralis OCT +HRA |
| Electroretinogram (ERG) | Rabbit, NHP* | Diagnosys Espion |
| Intra ocular pressure (IOP) | Rabbit, NHP* | Tonovet |
| Gene expression | Mouse and rat, (rabbit and NHP ex vivo) | IVIS Spectrum |
| COMPREHENSIVE DOSING TECHNIQUES | SPECIES |
|---|---|
| Topical eye | Mouse, rat, rabbit, NHP |
| Intravitreal injection | Mouse, rat, rabbit, NHP |
| Subretinal injection | Mouse, rat, rabbit, NHP |
| Subconjunctival injection | Mouse, rat, rabbit, NHP |
| Intracameral injection | Mouse, rat, rabbit, NHP |
| Suprachoroidal | Rabbit, NHP |
| Systemic delivery including oral, subcutaneous, intraperitoneal, intrathecal, intratracheal, and intravenous | Mouse, rat, rabbit, NHP |
GLOBAL PORTFOLIO OF CRO RESOURCES
SUPPORTING THE DEVELOPMENT OF
OPHTHALMIC DRUGS & DEVICES
(CH=China)
- Early discovery through phase I clinical studies
- GLP (CH)
- Efficacy and proof of concept studies
- Tolerance and safety studies
- Pharmacokinetics studies
- Genetic animal models
- Comprehensive dosing techniques
- State-of-the-art ocular technology
- Specialized surgical procedures
- Tissue collection and analysis
- Histology and pathology (CH)
OCULAR MODELS
- Dry Eye (CH)
- Allergic Conjunctivitis (MA, CH)
- Corneal Neovascularization (CH)
- Corneal Degeneration (CH)
- Cataract (CH)
- Uveitis (MA, CH)
- Acute & Chronic Glaucoma (MA, CH)
- Retinal Optic Nerve Damage (CH)
- Retinal Neovasularization (MA, CH)
- Retinopathy of Prematurity (CH)
- Diabetic Retinopathy (CH)
- Wet & Dry AMD (MA, CA)
White Papers
Webinars
Technical Sheet
Biomere Briefs
Subretinal Injection in a Sprague Dawley Rat
Subretinal Injection in a New Zealand White Rabbit
Subretinal Injection in a Rhesus Macaque
Posters
A Survey of Spontaneous Cataract in Senior Cynomolgus Monkeys with or without Diabetes
IOP-lowering Effect of Rhopressa® in Normotensive Rabbit, Dog and Monkey Eyes
Dry Eye in Ovariectomized Cynomolgus Monkeys – A 54 Months Follow-up Study
A long-acting anti-VEGF biologic in development for durable wet AMD treatment
