Metabolic Disorders

METABOLIC DISORDERS IN RODENTS

Dyslipidemia and Atherosclerosis Mice

  • Apo E -/-
  • LDLR -/-

Type 1 Diabetes models

  • Streptozotocin (STZ) mouse/rat

Mouse Models of Type 2 Diabetes

  • ob/ob: lacking leptin
  • db/db: lacking the leptin receptor

Rat Models of Type 2 Diabetes

  • ZDF: mutation in leptin receptor (fa/fa) spontaneously
    develops insulin resistance, hyperlipidemia and obesity

Models for Obesity

  • Diet-Induced Obesity Mice (DIO)
  • Zucker Fatty rats: hyperphagic and hyperinsulinemic
    without hyperglycemia

END POINTS FOR METABOLIC DISORDERS IN RODENTS

In Life Measurements

  • Body weights
  • Blood glucose measurements
  • Insulin levels
  • C-peptide
  • GTT (OGTT and ipGTT)
  • ITT
  • Hemoglobin A1c (HbA1c)
  • Metabolic cages
    – Urine and feces collection
  • Food and water consumption

Cytokine levels by ELISA

Clinical Pathology

  • HDL
  • LDL
  • Total cholesterol
  • Total triglyceride
  • Liver enzymes

Tissue Analysis (Subcontracted)

  • Immunohistochemistry (IHC)
  • Histopathology
The Effects of Positive Control in Mouse Models for Type 2 Diabetes
Rats Model for Type 2 Diabetes
Immunohistochemistry of the Pancreas in Type 2 Diabetes Rats

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