CRO Expertise
METABOLIC DISORDERS IN RODENTS
Dyslipidemia and Atherosclerosis Mice
- Apo E -/-
- LDLR -/-
Type 1 Diabetes models
- Streptozotocin (STZ) mouse/rat
Mouse Models of Type 2 Diabetes
- ob/ob: lacking leptin
- db/db: lacking the leptin receptor
Rat Models of Type 2 Diabetes
- ZDF: mutation in leptin receptor (fa/fa) spontaneously
develops insulin resistance, hyperlipidemia and obesity
Models for Obesity
- Diet-Induced Obesity Mice (DIO)
- Zucker Fatty rats: hyperphagic and hyperinsulinemic
without hyperglycemia
END POINTS FOR METABOLIC DISORDERS IN RODENTS
In Life Measurements
- Body weights
- Blood glucose measurements
- Insulin levels
- C-peptide
- GTT (OGTT and ipGTT)
- ITT
- Hemoglobin A1c (HbA1c)
- Metabolic cages
– Urine and feces collection - Food and water consumption
Cytokine levels by ELISA
Clinical Pathology
- HDL
- LDL
- Total cholesterol
- Total triglyceride
- Liver enzymes
Tissue Analysis (Subcontracted)
- Immunohistochemistry (IHC)
- Histopathology
Articles
Animal models of diabetic neuropathic pain
