CRO Expertise

METABOLIC DISORDERS IN RODENTS

Dyslipidemia and Atherosclerosis Mice

• Apo E -/-
• LDLR -/-

Type 1 Diabetes models

• Streptozotocin (STZ) mouse/rat

Mouse Models of Type 2 Diabetes

• ob/ob: lacking leptin
• db/db: lacking the leptin receptor

Rat Models of Type 2 Diabetes

• ZDF: mutation in leptin receptor (fa/fa) spontaneously
  develops insulin resistance, hyperlipidemia and obesity

Models for Obesity

• Diet-Induced Obesity Mice (DIO)
• Zucker Fatty rats: hyperphagic and hyperinsulinemic
  without hyperglycemia

END POINTS FOR METABOLIC DISORDERS IN RODENTS

In Life Measurements

• Body weights
• Blood glucose measurements
• Insulin levels
• C-peptide
• GTT (OGTT and ipGTT)
• ITT
• Hemoglobin A1c (HbA1c)
• Metabolic cages
  – Urine and feces collection
• Food and water consumption

Cytokine levels by ELISA

Clinical Pathology

• HDL
• LDL
• Total cholesterol
• Total triglyceride
• Liver enzymes

Tissue Analysis (Subcontracted)

• Immunohistochemistry (IHC)
• Histopathology

Articles

Animal models of diabetic neuropathic pain

Technical Sheets

Metabolic Disorders in Rodents

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