Different Types of Mouse Colonies for Specific Preclinical Studies
Mouse models are one of the mainstays of biological research and preclinical drug development. Mice are maintained and bred in colonies that are stringently maintained
Customized full-service mouse colony development, housing, breeding and care to ensure ready animal cohorts for PK/PD, toxicology and efficacy studies. We offer options to ship animal cohorts to third parties or clients, or perform DMPK and early toxicology studies in-house with priority scheduling.
Every client is assigned a dedicated team member, who is their single point of contact and directs the work of the project technicians and staff. Clients continuing their projects with Biomere receive priority on our study schedule, resulting in expedited starts for studies and more rapid generation of samples and data.
Biomere uses SoftMouse software to manage and track mouse colonies. This ensures accurate breeding, genotyping and colony development records. Clients receive custom inventory reports with detailed information, including genotypes, age, gender, lineage etc. Custom reports are also available upon client request.
Regardless of the size of your colony, we breed to your specifications within your timeline. Upon completion of your project, we will transfer your models in-house for a Biomere study or ship to the domestic or international location of choice.
The Biomere animal care teams can administer custom or specialized diets, water, supplements, medications and enrichment methods to ensure optimal animal health and study-ready animals.Biomere offers multiple housing options, including maximum exclusion for germ-fee animals; standard exclusion for Specific Pathogen Free (SPF) animals; or quarantine facilities that allow specific pathogens. Depending on health status, germ-free and SPF mice are housed in individually ventilated cages (IVCs), while quarantined mice are housed in rigid isolators. Â
Each client colony is well separated from other colonies, and occupies one side of the rack to ensure no cross-contamination. Biomere also offers genotyping services, using conventional and real-time PCR methods. Genetic background characterization using SNP (single nucleotide polymorphism) panels are also available.
The Biomere colony management team has expertise in specific reproductive technologies, including rederivation through embryo transfer; in vitro fertilization (IVF); cesarean delivery; and ovary transplantation. Fostering, timed pregnancies, embryonic and fetal tissue collection, blood, urine and tissue collection are also offered, as well as additional services catering to client needs as requested.The Biomere team has experience managing colonies of diverse rodent models, including neonate models, rare disease models, inducible and conditional expression models (Cre-Lox, Tet-Off/On), reporter models, and complex multi-gene and multi-knockout models. Experience in rat and mouse models from multiple areas of research, including:
Metabolic and liver diseases
Bone diseases
Immunology and Inflammation diseases
Neurological diseases
Eye diseases
Kidney diseases
Lung diseases
Genetically modified models
Mouse models are one of the mainstays of biological research and preclinical drug development. Mice are maintained and bred in colonies that are stringently maintained
Mouse models have been extensively used to study the onset and development of neuronal diseases, and evaluate response to therapies. These models of neurodegenerative disease
Biomere provides full-service, customized mouse colony management, including colony development, housing, breeding, and animal care, to produce study-ready cohorts for PK/PD, toxicology, and efficacy studies. Completed cohorts can be shipped to clients or third parties (domestic or international), or transferred in-house for Biomere-run DMPK and early toxicology studies with priority scheduling.
Yes. Through its Genetically Modified Animal Program (GMAP), Biomere manages diverse mouse models, including neonate models, rare disease models, inducible and conditional expression models (Cre-Lox, Tet-Off/On), reporter models (fluorescent and non-fluorescent), humanized gene models, and complex multi-gene and multi-knockout models, in both mice and rats.
Biomere has bred and managed rodent models across metabolic and liver diseases (including lysosomal storage, glycogen storage, and lipid metabolism disorders), bone diseases, immunology and inflammation (including clotting disorders and congenital anemias), neurological diseases (including neurodegenerative and motor neuron disease), eye diseases, kidney diseases (including urea cycle disorders), and lung and respiratory disorders.
Biomere uses SoftMouse software to manage and track mouse colonies, maintaining accurate breeding, genotyping, and colony development records. Clients receive custom inventory reports detailing genotype, age, gender, and lineage, with additional custom reports available on request.
Biomere offers maximum exclusion housing for germ-free animals, standard exclusion for Specific Pathogen Free (SPF) animals, and quarantine facilities for animals carrying specific pathogens. Germ-free and SPF mice are housed in individually ventilated cages (IVCs), while quarantined mice are housed in rigid isolators.
Each client colony is kept well separated from others and occupies one side of a rack to prevent cross-contamination. Housing is matched to health status, with IVCs for germ-free and SPF animals and rigid isolators for quarantined animals, to maintain biosecurity.
Biomere offers genotyping using both conventional and real-time PCR methods. Genetic background characterization using single nucleotide polymorphism (SNP) panels is also available.
Biomere’s colony management team has expertise in rederivation through embryo transfer, in vitro fertilization (IVF), cesarean delivery, and ovary transplantation. The team also provides fostering, timed pregnancies, embryonic and fetal tissue collection, and blood, urine, and tissue collection.
Yes. Regardless of colony size, Biomere breeds to client specifications within the client’s timeline. Custom or specialized diets, water, supplements, medications, and enrichment can be administered to support animal health and study readiness.
On project completion, Biomere can transfer your models in-house for a Biomere-run study, or ship them to a domestic or international location of your choice. In-house options include DMPK and early toxicology studies with priority scheduling.
Yes. Each client is assigned a dedicated team member who serves as a single point of contact and directs the project technicians and staff. Returning clients receive priority on the study schedule, which expedites study starts and speeds the generation of samples and data.
Yes. Beyond breeding and housing, Biomere can perform DMPK and early toxicology studies in-house with priority scheduling, and produces study-ready cohorts for PK/PD, toxicology, and efficacy studies. Clients with colonies onsite receive priority scheduling for CRO services. This lets clients manage colony development and downstream studies under a single CRO.
