![](https://biomere.com/wp-content/uploads/2023/07/gene-therapy.jpg)
CRO Expertise
Gene Therapy Overview
- Housing and breeding programs for transgenic lines
- Experience with administration of various client’s test articles for multiple
gene therapy methods e.g. CRISPR, AAV, Oligo, mRNA, RNAi, siRNA,
ceDNA, antisense - Proficient in multiple routes of administration of test materials for gene therapy
- Multiple tissue collections according to client requests
- Established and developed in-vitro assays to assess the efficiency of the
gene therapy treatments e.g. ammonia, hEPO, FIX, FVIII, PHE, luciferase - Evaluate test compound toxicity by clinical observations and laboratory
test e.g. liver enzymes
IVIS Imaging
![](https://biomere.wpengine.com/wp-content/uploads/2020/09/gt_.png)
Routes of Administration
- Intravenous
- Hydrodynamic intravenous
- Subcutaneous
- Oral gavage
- Intramuscular
- Nebulization
- Intravitreal
- Intrathecal
- Intratracheal
- Intraarticular
- Intranasal
- Intracerebral ventricular
Summary
Experience with multiple transgenic strains
Proficient with multiple dose administration methods
Established various in-vitro assays
IVIS imaging capabilities
White Papers
![](https://biomere.wpengine.com/wp-content/uploads/2020/09/Proper_model_GT-studies.jpg)
![ocular disease gene therapy](https://biomere.wpengine.com/wp-content/uploads/2020/08/Gene_Therapies_for_Eye_Diseases.jpg)
![cancer gene+cell therapy](https://biomere.wpengine.com/wp-content/uploads/2020/08/Gene__Cell_Therapies_for-Cancer.jpg)
![cell+gene therapy](https://biomere.wpengine.com/wp-content/uploads/2020/08/Gene__Cell_Therapies_for_Rare_Diseases.jpg)
![](https://biomere.com/wp-content/uploads/2021/04/wp_header.jpg)
![](https://biomere.com/wp-content/uploads/2021/04/wp_header.jpg)
![](https://biomere.com/wp-content/uploads/2021/04/wp_header.jpg)
Webinars
Casey Maguire, Harvard Medical School – Strategies for in vivo Barriers to Gene Therapy Vectors
Technical Sheet
Articles
AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear
Therapeutic efficacy in a hemophilia-B model
JOINN Locations
![Joinn Locations](https://biomere.com/wp-content/uploads/2023/07/JOINN-locations.jpg)