Different Types of Mouse Colonies for Specific Preclinical Studies
Chinese Mouse models are one of the mainstays of biological research and preclinical drug development. Mice are maintained and bred in colonies that are stringently
Biomere has evaluated a range of animal models for different disease areas, including obesity, cardiovascular disease, diabetes, autoimmune disease, hemophilia, kidney disease, skin conditions and ocular disease. Our team is continuously testing models of disease states, and collaborates with drug developers to use new models for preclinical PK/PD, efficacy and early toxicology studies. Contact us to discuss your study needs.
Obesity and related complications are of high interest, largely due to the clinical and commercial success of GLP-1-based therapies. As such, there is high interest in testing next-generation therapies in preclinical animal models. Metabolic disease models are typically classified into induced and engineered models – for example, diet is the primary stimulus to induce an obese phenotype, while genetically modified mice (such as ApoE variant mice) develop obesity when exposed to high fat diets.
Obesity and related complications are of high interest, largely due to the clinical and commercial success of GLP-1-based therapies. As such, there is high interest in testing next-generation therapies in preclinical animal models. Metabolic disease models are typically classified into induced and engineered models – for example, diet is the primary stimulus to induce an obese phenotype, while genetically modified mice (such as ApoE variant mice) develop obesity when exposed to high fat diets.
Biomere has experience working with the following models for obesity and related complications:
Disease Indication | Model | Species |
Obesity | Diet-Induced Obesity (DIO) | Mouse |
OB/OB Mice | Mouse | |
Hyperlipidemia & Hypercholesteremia | High-Fat, High-Calorie (HFHC) Diet in ApoE Mice
| Mouse |
Atherosclerosis |
Mouse models are widely used to study both type I and type II diabetes and related complications, and are either genetically engineered or induced. For example, Streptozotocin (STZ) destroys pancreatic beta-cells that produce insulin, mimicking type I diabetes. Type II diabetes models include ob/ob and db/db mice that are engineered to be leptin deficient and leptin receptor deficient, respectively. Since these mouse models recapitulate many hallmarks of diabetes, they are used to study related complications, such as delayed wound healing and kidney damage. More recently, these models are being used to study protective effects of GLP-1 therapies.
Biomere has evaluated the following models for diabetes and related complications:
Disease Indication | Model | Species |
Type I Diabetes Mellitus | STZ-Induced Diabetes | Mouse, Rat |
Type II Diabetes Mellitus | OB/OB Mice | Mouse |
DB/DB Mice | Mouse | |
Zucker Diabetic Fatty (ZDF) Rat | Rat | |
Diabetic Nephropathy | STZ Induction +Nephrectomy + High Salt Load | Mouse, Rat |
Delayed Diabetic Wound Healing | STZ Induction (Type I Diabetes) + Skin Excision | Rat |
Type II Diabetes (DB/DB Mouse or ZDF Rat) + Skin Excision | Mouse, Rat |
Rodent models of autoimmune disease are valuable tools to understand disease onset and development, and evaluate changes in the immune system, such as the development of autoantibodies and activated lymphocytes. While there are about 100 identified autoimmune diseases, Biomere has evaluated rodent models for commonly studied diseases listed below:
Disease Indication | Model | Species |
Rheumatoid Arthritis | CFA (Complete Freund’s Adjuvant) Induced Arthritis | Mouse, Rat |
Collagen Induced Arthritis | Mouse, Rat | |
Systemic Lupus Erythematosus (SLE) | MRL/Lpr mice that combines a spontaneous strain (MRL) and Fas mutation | Mouse |
Graft vs Host Disease (GvHD) | PBMC Transplants in Immune-Deficient Mice | Mouse |
Ulcerative Colitis | TNBS-Induced Colitis | Rat |
DSS (Dextran Sulfate Sodium) Induced Colitis | Mouse | |
Psoriasis | Imiquimod Induced (topical application) | Mouse |
Several animal species are commonly used to study ocular diseases, including rodents, rabbits, and primates. Primates are highly translational models because their ocular anatomy and physiology closely resemble those of humans and rabbits are also widely used in ocular research due to their large eye size and lack of tear ducts, which minimizes washout of topically applied drugs. In addition, rabbit eyes share similar tissue architecture and vascularization with human eyes. Disease-specific rodent models are valuable tools to study ocular diseases.
Biomere has a dedicated ocular research team with extensive expertise in both topical and specialty dosing techniques, including subretinal, intravitreal, intracameral, and subconjunctival administration. The team continually develops and evaluates new ocular disease models using advanced qualitative and quantitative assessment methods, such as optical coherence tomography (OCT), fundus and corneal imaging, electroretinography (ERG), and visual evoked potential (VEP) recordings.
Disease Indication | Model | Species |
Corneal Wound | Chemical or Mechanical Wounds | Rabbit |
Choroidal Neovasculaturization (CNV) | Laser induced CNV | Mouse, Rat |
Acute & Chronic Glaucoma | Silicon Oil Acute Glaucoma Trabecular Meshwork Laser Chronic Glaucoma | Mouse, Primate |
Dry AMD | Sodium Iodate | Rat |
Retinal Neovascularization (RNV) | DL-AAA (DL-2-aminoadipic acid) Induced | Rabbit |
Chemotherapy-induced blood disorders are commonly observed clinically, thus it is important to evaluate whether or not specific therapies induce blood disorders, such as anemia and thrombocytopenia. Additionally, mouse models, such as the Factor VIII knockout model, are used to evaluate if novel therapeutics, including viral and nonviral gene therapies, cause spontaneous bleeding or other blood issues. Biomere uses the F8KO model as well as multiple species to evaluate blood disorders caused by chemotherapeutic agents.
Disease Indication | Model | Species |
Coagulation Disorders | Hemophilia in F8KO (Factor VIII) Mice | Mouse |
Granuolocyte/Thrombocytopenia | Chemotherapy-Induced | Mouse |
Anemia | Chemotherapy-Induced | Mouse, Rat |
Kidney disease can be induced through multiple methods, including surgery (5/6 nephrectomy), ischemia triggered by tubule damage, or drugs like cisplatin. Additionally, diabetic mouse models can be induced via surgical ablation to develop kidney disease. Biomere has validated large and small animal models for acute kidney injury and chronic kidney disease.
Disease Indication | Model | Species |
Acute Kidney Injury Granuolocyte/Thrombocytopenia | Unilateral Renal Ischemia and Eperfusion | Rat |
Cisplatin-Induced injury | Mouse, Rat | |
Chronic Kidney Disease | 5/6 Nephrectomized | Rat |
To study skin conditions, rodent and large animal models are popular preclinical models. While swine are popular models for skin condition studies, due to similar tissue architecture, thickness and permeability as human skin, primate models can also be used for erythema studies.
Disease Indication | Model | Species |
Wound Healing | Skin Excision | Mouse, Rat |
Erythema | UV or Inflammation Induced Skin Redness | Primate |
Answer
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Complete listing of disease models including specific models and species is available on The Concourse, or contact Deborah Curry at dcurry@biomere.com
Complete listing of pharmacology models, including specific models and species is available on The Concourse, or contact Deborah Curry at dcurry@biomere.com
