In this webinar, Dr. Maguire discusses technological innovations in adeno-associated virus (AAV) vectors designed to address challenges in delivering AAV vectors to target organs and avoiding immune detection. He focuses on two approaches for improving AAV gene delivery to the central nervous system (CNS).

The first approach involves screening AAV capsid libraries in both in vitro and in vivo models to identify and validate clones with enhanced CNS delivery. The second approach uses extracellular vesicles or microvesicles to improve the efficiency of AAV delivery to multiple organs, including the brain, eye, liver, and inner ear.