NHP Overview

Non-Human Primate Program

NON-HUMAN PRIMATE PROGRAM

Biomere has the largest NHP facility in New England. Our NHP program includes a large colony of naïve and non-naïve cynomolgus and rhesus macaques supporting PK/PD discovery research. We utilize a variety of different compound administration and sample collection techniques. We are proficient in conducting xenograft studies, as well as large and varied tissue biopsy and intrathecal programs.

Our rapid study start time sets us apart and continues to be a reliable staple supporting our clients’ discovery-based NHP studies.

Examples of comparative PK and flow cytometry data below:

comparative PK and flow cytometry data
Dose-response PK profile of a novel αIIbβ3 antagonist* in cynomolgus monkeys by three different routes of administration

OVERVIEW

  • Specialty colonies (CSF ported)
  • PK/PD, early toxicology screening
  • Extensive surgical capabilities (e.g. CSF porting)
  • Biopsy techniques include liver (open surgery and percutaneous), spleen, muscle, skin and more
  • Clinical pathology and in-vitro laboratory services
  • Full reporting capabilities and fast turn-around data submission

COMPLIANCE & ACCREDITATION

  • AAALAC international accreditation
  • USDA registered facility
  • PHS OLAW assurance (MA)

ENRICHMENT PROGRAM

Enrichment is an integral part of daily husbandry and animal care. Our behavior and enrichment team partners with our animal care teams to assure enrichment programs are biologically relevant. Our programs provide opportunities for hiding, social interactions, species appropriate locomotion, manipulanda, foraging and feeding. These specialized programs prevent or reduce the occurrence abnormal behaviors and assure, through consistency, that enrichment value is not lost over time.

In addition to dietary enrichment, manipulanda objects, and hanging devices our NHPs are provided sensory enrichment tools that promote auditory, visual, olfactory and tactile stimulation. These can include but are not limited to television, music or species-relevant soundtracks, or novel scents. A favorite is our bubble machine. For all species enrichment devices are provided on a rotating schedule to maintain the novelty of the enrichment and to promote the psychological well-being of the animals.

NHP BEHAVIORAL PROGRAM

NHP behavior is monitored daily. Team members interact with the animals many times during the day, providing positive human contact such as regularly offering food treats and speaking calmly during all interactions. The team monitors the animals for any signs of abnormal behavior and/or alopecia. If a behavioral issue is identified, an individualized intervention plan is provided to the specific NHP. Overall, the low occurrence of abnormal behaviors in our colony are attributed to the excellent individualized care and acclimation to both study procedures and daily animal care tasks provided by our dedicated staff. Alopecia is rarely observed in our colony. The rare instances when alopecia is present, it’s mainly the effect of one social partner overgrooming the other.
Monkey

Our global liaison team paves the way to extended resources, abundant pharmacology models and budget friendly options seamlessly.