Autoimmune Models

The term autoimmunity refers to a failure of the body’s immune system to recognize its own cells and tissues as “self”. Instead, immune responses are launched against these cells and tissues as if they were foreign or invading bodies.

Animal models are used for the study of a number of human autoimmune diseases, including multiple sclerosis (EAE), type 1 diabetes (IDDM), rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE).

Key models offered at Biomere include:
  • Induced and Spontaneous IDDM rodent and NHP models.
  • MOG and PLP Induced models of EAE in rodents and marmosets.
  • CFA/IFA Induced models of RA in rodents and rabbits.
  • TNBS and DSS Inducible models of IBD in rodents
  • Inducible rodent models of SLE in both the NZB/W F1 and MRL/lpr mouse models.

Induced, spontaneous and genetically manipulated animal models can be purchased, developed and/or validated per request.