Surgical Services

Biomere’s Worcester facility is well-equipped with two dedicated surgical suites for large animals (NHPs, mini pigs); specialized vivarium floors for small animal work; state‐of‐the‐art perioperative care; anesthesia; imaging support; and expert surgical and technical teams to ensure reproducibility, welfare, and high data integrity. The facility is AAALAC accredited, OLAW assured, DEA licensed, and USDA registered.

We offer a broad suite of surgical models to support preclinical evaluation of medical devices and novel therapies across multiple therapeutic areas including, oncology, neurology, metabolic diseases, ocular diseases, etc. Our offerings include:

• Indwelling CSF catheter and port systems for repeated CSF sampling and CNS-targeted dosing
• Complex dosing routes that may require surgical placement, including intrathecal, intra-cisternal magna, intracerebroventricular, etc.
• A wide array of biopsy and tissue sampling methods (liver, spleen, muscle, skin, and solid organs), with both percutaneous and open surgical options
• Tissue injury/disease induction models, organ‐targeted delivery, and localized therapeutic interventions (e.g. bio-adhesives, interventional procedures)

Each dosing route has specific applications and the optimal route should be identified based on the species, study duration and test article: 

Once a surgical model is established, the surgical team works closely with the broader Biomere team to monitor the models through test article administration, in-life observations and sample collections, and performs complex terminal procedures and tissue collections.