Housing and breeding programs for transgenic lines
Experience with administration of various client’s test articles for multiple gene therapy methods e.g. CRISPR, AAV, Oligo, mRNA, RNAi, siRNA, ceDNA, antisense
Proficient in multiple routes of administration of test materials for gene therapy
Multiple tissue collections according to client requests
Established and developed in-vitro assays to assess the efficiency of the gene therapy treatments e.g. ammonia, hEPO, FIX, FVIII, PHE, luciferase
Evaluate test compound toxicity by clinical observations and laboratory test e.g. liver enzymes
IVIS IMAGING
Routes of Administration
Intravenous
Hydrodynamic intravenous
Subcutaneous
Oral gavage
Intramuscular
Nebulization
Intravitreal
Intrathecal
Intratracheal
Intraarticular
Intranasal
Intracerebral ventricular
Summary
Experience with multiple transgenic strains
Proficient with multiple dose administration methods
