Inflammation

CRO Expertise

INFLAMMATORY BOWEL DISEASE (IBD)

Inflammation is a vital part of the body’s immune response. It is the body’s attempt to heal itself after an injury; defend itself against foreign invaders, such as viruses and bacteria; and repair damaged tissue. Biomere’s interest in inflammatory disease stems from our expertise in autoimmunity.

We offer models of systemic lupus erythematosus (SLE) as well as antigen induced infl ammation such as collagen induced arthritis and myelin peptide-induced experimental autoimmune encephalomyelitis (EAE) as a model of multiple sclerosis. Additionally we offer chemically induced models of infl ammatory bowel disease (IBD)/ulcerative colitis and Type 1 diabetes.

INDUCIBLE MODELS

Acute 2,4 6-trinitrobenzenesulfonic acid (TNBS) hapten including IFN-γ, TNF-α, IL-2, IL-12 and IL-18

Acute dextran sulfate sodium (DSS)

IBD Readouts

IBD Disease Activity Index

Additional Analyses

Colon Evaluation

Microscopic Colon Scoring

DSS Induced IBD in Mice

TNBS-Induced IBD in Mice

Technical Sheets

EAE for MS

Inflammatory Bowel Disease